Job Description

Working with Us

Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

When you join BMS, you are joining a diverse, high-achieving team united by a common mission.

The Oncology Thematic Research Center at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies, and implement our discovery platforms across all of our therapeutic areas of focus. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

The new Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.

Here, you'll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

Position Summary

We are seeking an experienced individual with biologics drug discovery expertise to join the Discovery Biology team within the Oncology Thematic Research Center at Bristol-Myers Squibb in Cambridge, MA. The qualified candidate is a highly motivated, interactive, and creative scientist and with the ability to work across a highly matrixed organization to advance programs from target validation to lead optimization, selection of drug candidate and IND-enabling biology related activities.

This individual will be dedicated to designing and executing experimental studies related to the decisional progress of our programs from early stages all the way through IND filling. The candidate will be involved in executing biology bench studies that will advance the understanding of mechanism of action as well as developing several screening funnel assays that will enable compound triaging and identification of potential drug candidate. In addition, the individual will work closely with the informatics and predictive science, translational research, and lead optimization teams to design/execute work related to patient stratification, identification of appropriate in vitro PD markers and assay development/transfer for miniaturization.

Position Responsibilities

In the role as a Scientist within Discovery Biology, the ideal candidate:

• Uses current and new techniques for function-based identification and selection of antibody-drug-conjugate (ADC) lead drug candidates
• Applies extensive technical knowledge to address ADC mechanism of action and to establish PD/efficacy relationships
• Designs and executes molecular and cellular studies.
• Collaborates with rest of biology team members as well as other functional area leads e.g. pharmacology, DMPK, informatics and predictive science.
• Presents data in lab meetings as well as full team project meetings.
• Executes experiments independently, troubleshoot as needed, interpret, and discuss data.
• Utilizes excellent communication and interpersonal skills.
• Communicates via email, meetings, and reports.
• Conducts experimental work independently, with accurate, detailed record-keeping.
• Performs laboratory work related but not limited to tissue culture, qPCR, western blot, multi-parametric flow cytometry, immune cell culture using activation/expansion/exhaustion assays, proliferation and tumor killing assays, 2D/3D co-culture activity assays, ELISA, Luminex, processing of DNA/RNA/protein.

Experience

Basic Qualifications:

• Bachelor's Degree
  
  • 5+ years of academic and / or industry experience

Or

• Master's Degree
  
  • 3+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences
  
  • No experience necessary

Preferred Qualifications:

• Experience in oncology and immuno-oncology biologics drug discovery (antibody-drug-conjugates preferred).
• Proficient with expression modulation tools e.g. CRISPRs, shRNAs, siRNAs.
• Extensive knowledge of flow cytometry, Incucyte and high content imaging platforms
• Experienced in the design, development and optimization of high-throughput cell-based assays for antibody screening and ADC activity
• Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work.
• Ability to summarize and interpret scientific data in a clear, concise, and accurate manner.
• Excellent oral and written communication skills. Ability to communicate well with peers and supervisors.
• Strong problem-solving skills and understanding of relevant scientific principles.

#LI-Onsite

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as "Transforming patients' lives through science™ ", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information:

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Job Tags

Full time, Remote job, Shift work,

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